Brenda L. (MacDonald) LaDue, age 63, passed away on December 6, 2023 at Baystate Medical Center. She was born on January 6, 1960 in Holyoke, daughter of John C. MacDonald of Chicopee and the late Claire (Crochiere) MacDonald. She was also predeceased by her brother John MacDonald earlier this year and also by her granddaughter Nadia Ladue in 2010. Brenda worked as a registered nurse in the emergency department at Baystate Medical Center and then for Viability for many years before she retired. She is survived by her sons Jason Ladue and his wife Angela of Granby and Jeremy Ladue of Ludlow; one brother Darryl MacDonald and his wife Lynn of Chicopee; two sisters, Holly (MacDonald) Comtois of Chicopee and Karrie MacDonald and her husband Ori of Granby, CT. She also is survived by her three beloved grandchildren, Jason Jr and Aubrey Ladue of Granby, MA and Jonathan Ladue of FL, her nieces and nephews and her sister-in-law, Jessica MacDonald. A private memorial will be held at a later date. The Grise Funeral Home is entrusted with arrangements. For online condolences, please visit www.GriseFH.com.